Curable Layered Double Hydroxide Nanoparticles‐Based Perfusion Contrast Agents for X‐Ray Computed Tomography Imaging of Vascular Structures

Imaging complex vascular structures by X-ray microcomputed tomography (μ-CT) is becoming vital for research purposes in pathology of diseases. Acrylic-based polymerizable resins are widely adopted the contrast agent to prepare pathological specimens imaging structures. For at higher resolution, it promising develop inorganic-type agents with attenuation coefficient as well low viscosity, homogeneity, minimum shrinkage, curable (gellable) replication, and cost. Herein, a novel inorganic sol–gel system based on concentrated colloidal dispersion NiAl layered double hydroxide (LDH) nanoparticles described, allowing high resolution. LDH acts nanofiller alkaline catalyst form silica/LDH monolithic material homogeneity from nanoscale. Moreover, contribute strong enhancement attenuation. As proof-of-concept, μ-CT developed glass capillaries blood vessels human placenta murine liver demonstrated.